Caenorhabditis elegans
ABI-1
CELE_B0336.6, B0336.6
abi-1 encodes an Abl interactor orthologous to human SSH3BP1 (ABI1; OMIM:603050, mutated in acute myeloid leukemia), ABI-2 (OMIM:606442), and NESH (OMIM:606363); abi-1 is required for epidermal cell migrations during embryonic enclosure, proper migration of the excretory cell, distal tip cell, and mechanosensory and motoneurons, and apoptotic cell engulfment; ABI-1 physically interacts with the MIG-10 and the N-terminus of UNC-53/NAV2, which may provide a link between ABI-1, MIG-10 and the ARP2/3 complex; ABI-1 also physically interacts with the ABL-1 tyrosine kinase; ABI-1 is expressed in a number of head and nerve ring neurons including the amphid interneurons AIYL/R and the RMEL/R motoneurons, several types of ventral cord motoneurons and the coelomocytes; in neurons, ABI-1 localizes to the cell bodies, dendrites and commissural axons.
GO Process (15)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- body morphogenesis [IMP]
- cell migration [IGI]
- cell projection morphogenesis [IGI, IMP]
- embryo development [IMP]
- embryo development ending in birth or egg hatching [IMP]
- engulfment of apoptotic cell [IMP]
- hermaphrodite genitalia development [IMP]
- inductive cell migration [IMP]
- locomotion [IMP]
- nematode larval development [IMP]
- neuron migration [IMP]
- oviposition [IMP]
- positive regulation of engulfment of apoptotic cell [IGI]
- receptor-mediated endocytosis [IMP]
- reproduction [IMP]
Gene Ontology Molecular Function
Download Curated Data for this Protein
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- Interactors 34
- Interactions 45
- Network