Caenorhabditis elegans

ABI-1

CELE_B0336.6, B0336.6
abi-1 encodes an Abl interactor orthologous to human SSH3BP1 (ABI1; OMIM:603050, mutated in acute myeloid leukemia), ABI-2 (OMIM:606442), and NESH (OMIM:606363); abi-1 is required for epidermal cell migrations during embryonic enclosure, proper migration of the excretory cell, distal tip cell, and mechanosensory and motoneurons, and apoptotic cell engulfment; ABI-1 physically interacts with the MIG-10 and the N-terminus of UNC-53/NAV2, which may provide a link between ABI-1, MIG-10 and the ARP2/3 complex; ABI-1 also physically interacts with the ABL-1 tyrosine kinase; ABI-1 is expressed in a number of head and nerve ring neurons including the amphid interneurons AIYL/R and the RMEL/R motoneurons, several types of ventral cord motoneurons and the coelomocytes; in neurons, ABI-1 localizes to the cell bodies, dendrites and commissural axons.
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  • Interactors 34
  • Interactions 45
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