CELE_F37A4.8, F37A4.8

isw-1 encodes a chromatin remodeling protein containing an AT-hook, two SANT domains, a DEXD/H box, and an ATPase domain that is the C. elegans ortholog of Drosophila ISWI, human SNF2H, and Saccharomyces cerevisiae ISW2; ISW-1 likely acts as the ATPase component of a Nucleosome Remodeling Factor (NURF)-like complex also containing NURF-1 that antagonizes the action of synMuv (synthetic Multivulva) genes in regulating vulval cell fate specification and ISW-1 and NURF-1 appear also to act redundantly with other genes to promote Ras pathway activity during vulval development; reduction-of-function mutations in isw-1 also suppress several non-vulval abnormalities of class B synMuv mutants, including defects in the germline-versus-soma cell-fate decision and a larval arrest phenotype; ISW-1 is a widely expressed nuclear protein that associates with chromatin.

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