Caenorhabditis elegans
INA-1
CELE_F54G8.3, F54G8.3
ina-1 encodes one of two C. elegans alpha integrin subunits; during development, ina-1 activity is required for migration of a number of cell types, including neurons, coelomocyte precursors, and the distal tip cells of the somatic gonad; in addition, ina-1 is required for axon fasciculation and morphogenesis of structures such as the head, pharynx, egg-laying apparatus, and male tail; INA-1 coimmunoprecipitates with the PAT-3 beta integrin subunit suggesting that, in vivo, INA-1 and PAT-3 function as a heterodimer to regulate cell migration and tissue morphogenesis; INA-1 is expressed in many tissues, including neurons, the gonad, and the pharyngeal basement membrane; expression begins during gastrulation and continues through to adulthood.
GO Process (14)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- axonal fasciculation [IMP]
- body morphogenesis [IMP]
- cell-cell adhesion mediated by integrin [IMP]
- hermaphrodite genitalia development [IMP]
- inductive cell migration [IMP]
- locomotion [IMP]
- mesodermal cell migration [IMP]
- nematode larval development [IMP]
- nematode male tail tip morphogenesis [IMP]
- neuron migration [IMP]
- organ morphogenesis [IMP]
- protein catabolic process [IMP]
- receptor-mediated endocytosis [IMP]
- reproduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
41495
6239
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- Interactors 4
- Interactions 5
- Network