CELE_T21C12.2, T21C12.2

hpd-1 encodes a putative 4-hydroxyphenylpyruvate dioxygenase required for normally short lifespan and for negative regulation of the dauer larval stage, with loss of hpd-1 function prolonging lifespan and promoting dauer formation; hpd-1 is a (perhaps evolutionarily conserved) target of transcriptional activation by DAF-16; HPD-1 is orthologous to human HPD (OMIM:609695, mutated in tyrosinemia type III), and is paralogous to C31H2.4 and human HPDL/GLOXD1; HPD-1 is expressed in hypodermis and intestine, and is required for the tyrosinemic phenotype of K10C2.4(RNAi) animals.

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