CELE_Y55F3AM.12, dcp1, Y55F3AM.12

dcap-1 encodes an ortholog of budding yeast Dcp1p and human DCP1A (OMIM:607010) and DCP1B (OMIM:609843); DCAP-1 is expressed in diverse tissues, including muscle, intestine, neurons, and the reproductive system; DCAP-1 is colocalized with CAR-1 to P granules, and with AIN-1 and CAR-1 to discrete cytoplasmic foci that resemble P bodies; although it is orthologous to mRNA decapping complex subunits, DCAP-1 itself shows no decapping activity in vitro on either m7GpppG- or m2,2,7GpppG-capped RNAs; however, dcap-1(RNAi) shows weak synthetic lethality with dcap-2(RNAi), suggesting that DCAP-1 and DCAP-2 are partially redundant in vivo.

42082

6239