CELE_F38A5.13, F38A5.13

dnj-11 encodes a protein containing DnaJ and Myb domains that is orthologous to the mammalian ZRF1/MIDA1/MPP11/DNAJC2 family of ribosome-associated molecular chaperones; in C. elegans, dnj-11 functions to regulate asymmetric cell division and mitotic spindle orientation in the NSM neuroblast and subsequently the apoptotic death of the NSM sister cell; in regulating NSM sister cell death, DNJ-11 functions together with CES-2 to negatively regulate ces-1 transcription in the NSM lineage; in addition to its role in NSM lineage cell fate, dnj-11 activity is also required generally for embryonic development, growth, reproduction, body morphology, and vulval development; a DNJ-11::GFP reporter fusion is expressed in nearly all somatic cells of embryos, larvae, and adults, and localizes to the cytosol; as dnj-11 mutations are maternally rescuable, dnj-11 is also likely expressed in the germline.

42539

6239