CELE_C07G1.5, pqn-9, vps-27, C07G1.5

hgrs-1 encodes a VHS and FYVE zinc finger-domain containing protein that is the C. elegans ortholog of S. cerevisiae Vps27p and mammalian hepatocyte growth factor-regulated tyrosine kinase substrate (HGS); hgrs-1 activity is essential for molting and thus for proper larval development; consistent with its proposed role in the endocytic pathway, HGRS-1 is also required for proper trafficking of the LRP-1 low-density lipoprotein receptor-related protein 1 and for endosome maturation and regulation of autophagic vesicle accumulation; an HGRS-1::GFP fusion protein is widely expressed, but particularly enriched in epithelial cells; within cells, HGRS-1::GFP localizes to endosomal membranes; HGRS-1 and STAM-1 physically interact in vivo, forming the C. elegans ESCRT-0 complex; on early endosomes; in the context of the complex, both STAM-1 and HGRS-1 bind ubiquitin.

42730

6239