CELE_W01B6.9, cogc-7, W01B6.9

ndc-80 (cogc-7) encodes an ortholog of mammalian COG-7 (OMIM:606978, mutated in congenital disorder of glycosylation), a subunit of lobe B of the conserved oligomeric Golgi complex (COGC); NDC-80 is also an outer kinetochore component orthologous to S. cerevisiae Ndc80p; NDC-80 affects metaphase plate formation in embryos (thus affecting chromosome segregation), kinetochore-microtubule interactions, locomotion, vulval development, body morphology, and embryonic viability; NDC-80 is weakly required for normal gonadal distal tip cell migration, a process that also requires seven other orthologs of COGC subunits; like other lobe B subunits in both C. elegans and S. cerevisiae, NDC-80 is only partially required for normal function, while lobe A subunits are strongly required in either worms or yeast; NDC-80 interacts in vivo with KNL-1, HIM-10, and a homolog of Nuf2p, and NDC-80 and HIM-10 are codependent for kinetochore assembly.

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