CELE_K04D7.1, K04D7.1

rack-1 encodes a seven-WD repeat-containing protein that is the C. elegans ortholog of vertebrate Receptor for Activated C Kinase (Rack1); rack-1 is required cell autonomously for VD/DD motor axon pathfinding; rack-1 is also required for gonadal distal tip cell migration and for normal brood sizes; genetic analyses indicate that rack-1 functions in the same pathway with ced-10/Rac and unc-115/abLIM, and in parallel to mig-2/RhoG and unc-34/Enabled, to control axon pathfinding; in regulating axon pathfinding, RACK-1 likely acts upstream of UNC-115 with which it physically interacts; rack-1 also acts downstream of, or with, unc-115 to regulate P cell nuclear migration; in regulating gonadal distal tip cell migration, rack-1 acts either independently of, or in the same pathway as, ced-10 and mig-2; rack-1::gfp is expressed in most, if not all, tissues, and a RACK-1::GFP localizes to the cytoplasm, with some fusion protein also seen in the axons, cell bodies, and growth cones of migrating VD neurons.

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