CELE_F38H4.9, F38H4.9

let-92 encodes a homolog of PP2AC, the catalytic subunit of protein phosphatase 2A (PP2A); let-92 was identified genetically in screens for essential genes on chromosome IV; LET-92 may regulate a number of signal transduction pathways as it is required for embryogenesis, larval development, Ras-mediated vulval development, and axonal guidance in the DD and VD neurons; let-92 interacts genetically with sur-6 which encodes a regulatory subunit of PP2A; LET-92 physically interacts with the PP2A regulatory subunit RSA-1 and also with SMG-2, POS-1, UNC-51, and UNC-14; LET-92 is expressed cytoplasmically in nearly all cells and strongly in many neurons; LET-92 is also seen on centrosomes and P granules; LET-92, and possibly other phosphatases, and the PAR-1 protein kinase regulate the MEX-5 gradient in the early embryo by controlling the association of MEX-5 with slow- and fast-diffusing RNA-containing cytoplasmic complexes.

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