Caenorhabditis elegans
RAB-1
CELE_C39F7.4, C39F7.4
rab-1 encodes an ortholog of the small Ras-like GTPase Rab1; by homology, RAB-1 is predicted to play a role in intracellular vesicle trafficking, and consistent with this broad role, large-scale RNAi screens indicate that rab-1 activity is required for fertility, movement, and survival; in yeast two-hybrid assays, RAB-1 interacts with TIR-1, a C. elegans SARM ortholog that is required for innate immunity; RNAi studies suggest that RAB-1 and TIR-1 likely function in a pathway that controls expression of antimicrobial peptides such as NLP-29 and NLP-31; rab-1 also appears to play a role in regulating polyglutamine protein aggregation, as rab-1(RNAi) animals show premature accumulation of protein aggregates; in situ hybridization studies indicate that rab-1 is broadly expressed, with elevated levels apparent in the germline.
GO Process (10)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
- apoptotic process [IMP]
- body morphogenesis [IMP]
- developmental process [IMP]
- embryo development ending in birth or egg hatching [IMP]
- locomotion [IMP]
- molting cycle, collagen and cuticulin-based cuticle [IMP]
- nematode larval development [IMP]
- oogenesis [IMP]
- receptor-mediated endocytosis [IMP]
- reproduction [IMP]
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- Interactors 18
- Interactions 18
- Network