CELE_F56F10.4, F56F10.4

lgl-1 encodes a protein that is related to the Drosophila tumor suppressor Lethal giant larvae (Lgl), a basolateral junction component that regulates cell polarity by controlling localization of proteins to specific regions of the plasma membrane; lgl-1 functions redundantly with par-2 to generate and maintain cell polarity in the early elegans embryo; lgl-1 is involved in the asymmetric partitioning of the PAR (PAR-3/PAR-6/PKC-3) complex most likely by associating with PAR-6 and PKC-3; the association of lgl-1 with the PAR complex is dependent on phosphorylation of lgl-1 by PKC-3; lgl-1 is also required for the proper localization of myosin NMY-2; lgl-1 localizes asymmetrically to the posterior cortex in a PKC-3 dependent manner.

45388

6239