CELE_Y41G9A.1, Y41G9A.1

osm-5 encodes the ortholog of the murine polycystic kidney disease gene Tg737 (which encodes the protein Polaris) and human IFT88; osm-5 is required for the proper morphology of the cilia of chemosensory neurons and is involved in intraflagellar transport; the abnormalities in cilia structure in osm-5 mutants lead to defects in several processes like osmotic avoidance, chemotaxis, dauer formation, male mating and life span; osm-5 is expressed in ciliated sensory neurons and localizes to the transition zones of the amphids, phasmids, labials and rays of the male tail; osm-5 expression is regulated by the RFX-type transcription factor, DAF-19, that also regulates the expression of other genes involved in cilia formation.

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