Caenorhabditis elegans
UNC-6
CELE_F41C6.1, unc-106, F41C6.1
unc-6 encodes a netrin orthologous to the human and mouse netrin-1 precursor proteins; UNC-6 functions as a guidance molecule that regulates circumferential axon migrations as well as migration of mesodermal cells, such as the gonadal distal tip cell, along the dorsoventral axis; in addition, UNC-6 mediates anchor cell (AC) invasion by regulating localization of the UNC-40 netrin receptor to the invasive plasma membrane of the AC, allowing for subsequent formation of an invasive membrane domain; a secreted molecule, UNC-6 is first expressed during embryogenesis in ventral epidermoblasts; additional expression is seen in neurons and sheath cells; UNC-6 is involved in both attractive and repulsive interactions mediated by the UNC-40 and UNC-5 netrin receptors, respectively.
GO Process (10)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
- axon guidance [IMP]
- dorsal/ventral axon guidance [IGI, IMP]
- gonad morphogenesis [IGI, IMP]
- locomotion [IMP]
- mesodermal cell migration [IMP]
- motor neuron axon guidance [IMP]
- nematode male tail tip morphogenesis [IMP]
- neuron projection development [IMP]
- protein catabolic process [IMP]
- regulation of cell migration [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
45889
6239
Switch View:
- Interactors 4
- Interactions 5
- Network