CELE_F08F1.8, F08F1.8

tth-1 encodes a thymosin beta ortholog that contains four functionally distinct thymosin beta repeats; in vitro, TTH-1 binds multiple actin monomers as well as filamentous actin suggesting that, as its homology predicts, TTH-1 plays a direct role in regulating actin polymerization and cytoskeletal organization in C. elegans; consistent with this, loss of tth-1 activity via a deletion mutation that removes upstream sequences results in animals with a dumpy morphology that are sterile as a result of maternal effect lethality associated with deformed oocytes containing abnormally distributed actin; tth-1 mRNA is present throughout development, while TTH-1 protein is detected in the adult gonad in the inside edges of the membranous structures surrounding germline nuclei, the cytoplasm and cortex of oocytes, early embryos at points of cell contact, the developing nerve ring, and then throughout the larval and adult body, with specific enrichment in the intestine and spermatheca.

46019

6239