frpr-20, CELE_C30B5.5, C30B5.5

daf-37 encodes a G-protein coupled receptor (GPCR) that belongs to the serpentine receptor class w (Srw) family of chemoreceptors; daf-37 functions in dauer signaling, upstream of the daf-11/guanylyl cyclase, daf-7/TGF-beta, and daf-2/insulin signaling pathways; daf-37 specifically senses and binds to a ascaroside (ascr#2), ascarosides are the major small-molecule components of the dauer pheromone and control developmental diapause (dauer), olfactory learning, social behavior and lifespan; cell-specific overexpression studies indicate that DAF-37 regulates dauer when expressed in ASI neurons and adult behavior when expressed in ASK neurons; daf-37 heterodimerizes with daf-38 (a GPCR with homology to human gonadotropin-releasing hormone receptor that participates in perception of ascr#2 as well as other ascarosides), most likely to form a functional receptor complex; daf-37 and daf-38 are expressed in chemosensory neurons.

47875

6239