CELE_F35D2.4, F35D2.4

mks-3 encodes a transmembrane domain protein homologous to the human ciliopathy protein MKS-3/tmem67/meckelin; MKS-3 is required for cilia-mediated chemosensory reception and for the normal length of cilia; in regulating cilia organization and function, mks-3 functions in the same pathway as other mks (Meckel-Gruber Syndrome (MKS) homolog genes), including mks-1, but in parallel to the nphp (nephronophthisis (human kidney disease) homolog) genes, nphp-1 and nphp-4; mks-1;nphp-4 double mutants also display cell autonomous defects in connections between sheath and socket cells; MKS-3 is expressed in ciliated sensory neurons where it localizes to the distal end of dendrites and the cilium base; mks-3 expression is dependent upon the DAF-19 RFX-type transcription factor.

50055

6239