CELE_Y71G12B.16, Y71G12B.16

drag-1 encodes the C. elegans homolog of a putative GPI-anchor protein of the RGM family, a membrane associated protein that functions as co-receptor in the the Sma/Mab pathway; drag-1 mutants exhibit a subset of phenotypes seen in mutants in the Sma/Mab pathway like smaller than wildtype worm phenotype throughout the larval development, the males could mate and have no male tail patterning defects; drag-1 genetically interacts with daf-7 and daf-1 mutants in dauer pathway; drag-1 likely acts upstream of lon-1, but in parallel to lon-2 and dbl-1 suggesting that it is functioning at the ligands-receptor level in the Sma/Mab pathway to regulate body size; Drag-1 functions in the same cells as the Sma-9 and Sma/Mab receptors and SMAD proteins to regulate body size; DRAG-1 is not only present but also functions at the cell membrane; DRAG-1 is a positive regulator of the sma/Mab pathway; drag-1p::gfp is expressed in pharyngeal, hypodermal and intestinal cells as like sma-6 in hermaphrodites, but not in male tail cells.

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