BAIT
ZDHHC17
HIP14, HIP3, HYPH, HSPC294
zinc finger, DHHC-type containing 17
GO Process (5)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SMARCB1
BAF47, INI1, MRD15, PPP1R144, RDT, RTPS1, SNF5, SNF5L1, SWNTS1, Sfh1p, Snr1, hSNFS
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
GO Process (13)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [IBA, IDA]
- DNA integration [TAS]
- DNA repair [IBA]
- cell differentiation [IBA]
- chromatin remodeling [IDA]
- mitotic cell cycle phase transition [IBA]
- negative regulation of cell proliferation [IBA]
- nucleosome disassembly [IDA]
- positive regulation by host of viral transcription [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription from RNA polymerase II promoter [NAS]
- single stranded viral RNA replication via double stranded DNA intermediate [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.
HIP14 is the most highly conserved of 23 human palmitoyl acyltransferases (PATs) that catalyze the post-translational addition of palmitate to proteins, including huntingtin (HTT). HIP14 is dysfunctional in the presence of mutant HTT (mHTT), the causative gene for Huntington disease (HD), and we hypothesize that reduced palmitoylation of HTT and other HIP14 substrates contributes to the pathogenesis of the disease. ... [more]
Hum. Mol. Genet. Aug. 01, 2014; 23(15);4142-60 [Pubmed: 24705354]
Throughput
- High Throughput
Curated By
- BioGRID