BAIT
ZDHHC17
HIP14, HIP3, HYPH, HSPC294
zinc finger, DHHC-type containing 17
GO Process (5)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RANGRF
HSPC236, MOG1, RANGNRF, HSPC165
RAN guanine nucleotide release factor
GO Process (11)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- ER to Golgi vesicle-mediated transport [IMP]
- positive regulation of GTPase activity [ISS]
- positive regulation of establishment of protein localization to plasma membrane [IMP]
- positive regulation of protein localization to cell surface [IDA, IMP]
- protein exit from endoplasmic reticulum [IMP]
- regulation of heart rate [TAS]
- regulation of membrane depolarization [IDA, IMP]
- regulation of membrane depolarization during cardiac muscle cell action potential [TAS]
- regulation of membrane potential [IDA]
- regulation of sodium ion transmembrane transport [IDA, IMP]
- regulation of sodium ion transmembrane transporter activity [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.
HIP14 is the most highly conserved of 23 human palmitoyl acyltransferases (PATs) that catalyze the post-translational addition of palmitate to proteins, including huntingtin (HTT). HIP14 is dysfunctional in the presence of mutant HTT (mHTT), the causative gene for Huntington disease (HD), and we hypothesize that reduced palmitoylation of HTT and other HIP14 substrates contributes to the pathogenesis of the disease. ... [more]
Hum. Mol. Genet. Aug. 01, 2014; 23(15);4142-60 [Pubmed: 24705354]
Throughput
- High Throughput
Curated By
- BioGRID