BAIT

AT3G52640

Zn-dependent exopeptidases superfamily protein
GO Process (0)
GO Function (0)
GO Component (5)

Gene Ontology Cellular Component

Arabidopsis thaliana (Columbia)
PREY

AT2G31440

T28P16.7, T28P16_7
hypothetical protein
GO Process (0)
GO Function (0)
GO Component (0)
Arabidopsis thaliana (Columbia)

FRET

An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.

Publication

Gamma-secretase subunits associate in intracellular membrane compartments in Arabidopsis thaliana.

Smolarkiewicz M, Skrzypczak T, Michalak M, Lesniewicz K, Walker JR, Ingram G, Wojtaszek P

Gamma-secretase is a multisubunit complex with intramembrane proteolytic activity. In humans it was identified in genetic screens of patients suffering from familial forms of Alzheimer's disease, and since then it was shown to mediate cleavage of more than 80 substrates, including amyloid precursor protein or Notch receptor. Moreover, in animals, γ-secretase was shown to be involved in regulation of a ... [more]

J. Exp. Bot. Jul. 01, 2014; 65(12);3015-27 [Pubmed: 24723404]

Throughput

  • Low Throughput

Additional Notes

  • BiFC assay

Curated By

  • BioGRID