BAIT

MAEL

CT128, SPATA35, RP11-102C16.1
maelstrom spermatogenic transposon silencer
GO Process (4)
GO Function (0)
GO Component (4)
Homo sapiens
PREY

DDX3X

CAP-Rf, DBX, DDX14, DDX3, HLP2
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
GO Process (29)
GO Function (14)
GO Component (6)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Proteomic analysis reveals that MAEL, a component of nuage, interacts with stress granule proteins in cancer cells.

Yuan L, Xiao Y, Zhou Q, Yuan D, Wu B, Chen G, Zhou J

The Maelstrom (MAEL) gene is a cancer-testis (or cancer-germline) gene, which is predominantly expressed in germline cells under normal conditions, but is aberrantly expressed in a range of human cancer cells. In germline cells, MAEL is found predominantly in the nuage, where it plays an essential role in piRNA biogenesis and piRNA-mediated silencing of transposons. However, the role of MAEL ... [more]

Oncol. Rep. Jan. 01, 2014; 31(1);342-50 [Pubmed: 24189637]

Throughput

  • Low Throughput

Curated By

  • BioGRID