BAIT
NPHP1
JBTS4, NPH1, SLSN1
nephronophthisis 1 (juvenile)
GO Process (8)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BCAS3
GAOB1, MAAB
breast carcinoma amplified sequence 3
GO Process (17)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- Golgi organization [ISS]
- activation of Cdc42 GTPase activity [ISS]
- cellular response to estrogen stimulus [IDA]
- microtubule organizing center organization [ISS]
- negative regulation of Rho GTPase activity [ISS]
- negative regulation of focal adhesion assembly [ISS]
- positive regulation of Cdc42 GTPase activity [ISS]
- positive regulation of actin cytoskeleton reorganization [ISS]
- positive regulation of catalytic activity [IDA]
- positive regulation of endothelial cell migration [ISS]
- positive regulation of filopodium assembly [ISS]
- positive regulation of intracellular protein transport [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of establishment of cell polarity [ISS]
- response to starvation [IBA]
- tube formation [ISS]
- vesicle-mediated transport [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.
The centrosome is the primary microtubule organizing center of the cells and templates the formation of cilia, thereby operating at a nexus of critical cellular functions. Here, we use proximity-dependent biotinylation (BioID) to map the centrosome-cilium interface; with 58 bait proteins we generate a protein topology network comprising >7,000 interactions. Analysis of interaction profiles coupled with high resolution phenotypic profiling implicates a ... [more]
Cell Dec. 03, 2015; 163(6);1484-99 [Pubmed: 26638075]
Throughput
- High Throughput
Additional Notes
- BioID
Curated By
- BioGRID