BAIT
APC
AI047805, AU020952, AW124434, CC1, Min, mAPC
adenomatosis polyposis coli
GO Process (59)
GO Function (9)
GO Component (30)
Gene Ontology Biological Process
- T cell differentiation in thymus [IMP]
- Wnt signaling pathway [IDA, IMP]
- anterior/posterior pattern specification [IMP]
- axis specification [IMP]
- axonogenesis [IGI, IMP]
- canonical Wnt signaling pathway [IMP]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [IGI]
- canonical Wnt signaling pathway involved in positive regulation of apoptotic process [IGI]
- cell cycle arrest [ISO]
- cell migration [IMP, ISO]
- cellular response to DNA damage stimulus [ISO]
- chromosome organization [IGI, IMP]
- cytoplasmic microtubule organization [IGI]
- dorsal/ventral pattern formation [IMP]
- establishment or maintenance of cell polarity [ISO]
- hair follicle development [IMP]
- kidney development [IMP]
- metaphase/anaphase transition of mitotic cell cycle [IGI, IMP]
- mitotic cytokinesis [IMP, ISO]
- mitotic spindle assembly checkpoint [ISO]
- muscle cell cellular homeostasis [IGI]
- negative regulation of MAPK cascade [IGI, IMP]
- negative regulation of Wnt signaling pathway [IGI, IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of canonical Wnt signaling pathway [IMP, ISO]
- negative regulation of cell proliferation [IGI, IMP, ISO]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [ISO]
- negative regulation of epithelial cell proliferation [IGI, IMP]
- negative regulation of epithelial cell proliferation involved in prostate gland development [IMP]
- negative regulation of microtubule depolymerization [IMP, ISO]
- negative regulation of odontogenesis [IMP]
- neuron projection development [ISO]
- pattern specification process [IMP]
- positive regulation of apoptotic process [IMP, ISO]
- positive regulation of cell adhesion [IMP]
- positive regulation of cell differentiation [IMP]
- positive regulation of cell division [IMP]
- positive regulation of cell migration [IMP, ISO]
- positive regulation of epithelial cell differentiation [IGI]
- positive regulation of microtubule polymerization [IMP]
- positive regulation of protein catabolic process [IMP, ISO]
- positive regulation of pseudopodium assembly [ISO]
- protein complex assembly [ISO]
- proximal/distal pattern formation [IMP]
- regulation of attachment of spindle microtubules to kinetochore [IMP, ISO]
- regulation of cell cycle [IMP]
- regulation of cell differentiation [IGI]
- regulation of cell migration [IGI, IMP]
- regulation of epithelial cell differentiation [IMP]
- regulation of glutamate metabolic process [ISO]
- regulation of microtubule-based process [ISO]
- regulation of nitrogen compound metabolic process [IMP]
- regulation of osteoblast differentiation [IMP]
- regulation of osteoclast differentiation [IMP]
- retina development in camera-type eye [IMP]
- skin development [IMP]
- somatic stem cell maintenance [IGI, IMP]
- stem cell maintenance [IMP]
- thymus development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Scrib-APC-beta-catenin complex [IDA]
- axon [IDA]
- axonal growth cone [IDA, ISO]
- beta-catenin destruction complex [ISO]
- cell [IGI]
- cell body fiber [ISO]
- cell cortex [ISO]
- cell projection [IDA]
- cell projection membrane [IDA]
- cell-cell adherens junction [ISO]
- centrosome [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic microtubule [IDA]
- dendrite [ISO]
- growth cone [IDA, ISO]
- kinetochore [ISO]
- lamellipodium [ISO]
- lateral plasma membrane [ISO]
- microtubule [ISO]
- microtubule plus-end [IDA]
- neuron projection [ISO]
- neuron projection terminus [ISO]
- neuronal cell body [ISO]
- nuclear membrane [ISO]
- nucleus [IDA, ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- ruffle membrane [ISO]
- synapse [ISO]
- tight junction [ISO]
Mus musculus
PREY
JUP
ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB
junction plakoglobin
GO Process (20)
GO Function (9)
GO Component (17)
Gene Ontology Biological Process
- adherens junction organization [TAS]
- bundle of His cell to Purkinje myocyte communication [IMP]
- cell junction assembly [TAS]
- cell migration [IMP]
- cell-cell junction organization [TAS]
- cellular response to indole-3-methanol [IDA]
- cytoskeletal anchoring at plasma membrane [NAS]
- desmosome assembly [IDA, IMP]
- detection of mechanical stimulus [IDA]
- endothelial cell-cell adhesion [ISS]
- establishment of protein localization to plasma membrane [IMP]
- positive regulation of canonical Wnt signaling pathway [IC]
- positive regulation of protein import into nucleus [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IBA]
- regulation of cell fate specification [IBA]
- regulation of cell proliferation [IDA]
- regulation of heart rate by cardiac conduction [IMP]
- single organismal cell-cell adhesion [IDA, IMP]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- catenin complex [IDA]
- cell-cell adherens junction [IDA]
- cell-cell junction [IDA]
- cytoplasm [IMP]
- cytoplasmic side of plasma membrane [ISS]
- cytoskeleton [ISS]
- cytosol [ISS]
- desmosome [IDA]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- gamma-catenin-TCF7L2 complex [IDA]
- hemidesmosome [ISS]
- intercalated disc [IDA]
- nucleus [IMP]
- plasma membrane [IDA, TAS]
- protein-DNA complex [IDA]
- zonula adherens [ISS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have generated a library of HeLa cell lines expressing 1,125 GFP-tagged proteins ... [more]
Cell Oct. 22, 2015; 163(3);712-23 [Pubmed: 26496610]
Throughput
- High Throughput
Additional Notes
- interaction detected by quantitative BAC-GFP interactomics (QUBIC)
Curated By
- BioGRID