EXD2
Gene Ontology Biological Process
Gene Ontology Molecular Function
MRE11A
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [TAS]
- DNA duplex unwinding [IMP]
- DNA recombination [TAS]
- DNA repair [TAS]
- base-excision repair [IBA]
- cellular response to DNA damage stimulus [IDA]
- double-strand break repair [IBA, TAS]
- double-strand break repair via homologous recombination [TAS]
- double-strand break repair via nonhomologous end joining [TAS]
- innate immune response [TAS]
- intra-S DNA damage checkpoint [IBA]
- negative regulation of DNA endoreduplication [IMP]
- nucleic acid phosphodiester bond hydrolysis [IBA, TAS]
- nucleotide-excision repair [IBA]
- positive regulation of kinase activity [IDA]
- positive regulation of protein autophosphorylation [IDA]
- positive regulation of type I interferon production [TAS]
- reciprocal meiotic recombination [TAS]
- regulation of mitotic recombination [TAS]
- sister chromatid cohesion [IMP]
- telomere maintenance [IBA]
- telomere maintenance via telomerase [TAS]
Gene Ontology Molecular Function- 3'-5' exonuclease activity [IBA]
- ATP-dependent DNA helicase activity [IMP]
- DNA binding [IDA]
- double-stranded DNA binding [TAS]
- endodeoxyribonuclease activity [TAS]
- endonuclease activity [IBA]
- nuclease activity [TAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- single-stranded DNA endodeoxyribonuclease activity [TAS]
- 3'-5' exonuclease activity [IBA]
- ATP-dependent DNA helicase activity [IMP]
- DNA binding [IDA]
- double-stranded DNA binding [TAS]
- endodeoxyribonuclease activity [TAS]
- endonuclease activity [IBA]
- nuclease activity [TAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- single-stranded DNA endodeoxyribonuclease activity [TAS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
EXD2 promotes homologous recombination by facilitating DNA end resection.
Repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is critical for survival and genome stability of individual cells and organisms, but also contributes to the genetic diversity of species. A vital step in HR is MRN-CtIP-dependent end resection, which generates the 3' single-stranded DNA overhangs required for the subsequent strand exchange reaction. Here, we identify EXD2 (also known ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID