BAIT

DCUN1D4

DCN1, defective in cullin neddylation 1, domain containing 4
UPS Project
GO Process (0)
GO Function (1)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

CAND1

TIP120, TIP120A
cullin-associated and neddylation-dissociated 1
UPS Project
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.

Keuss MJ, Thomas Y, Mcarthur R, Wood NT, Knebel A, Kurz T

Cullin-RING ligases (CRL) are ubiquitin E3 enzymes that bind substrates through variable substrate receptor proteins and are activated by attachment of the ubiquitin-like protein NEDD8 to the cullin subunit. DCNs are NEDD8 E3 ligases that promote neddylation. Mammalian cells express five DCN-like (DCNL) proteins but little is known about their specific functions or interaction partners. We found that DCNLs form ... [more]

J. Cell. Sci. Apr. 01, 2016; 129(7);1441-54 [Pubmed: 26906416]

Throughput

  • High Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
DCUN1D4 CAND1
Reconstituted Complex
Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Low-BioGRID
1521267

Curated By

  • BioGRID