CDKN3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ROCK1
Gene Ontology Biological Process
- Rho protein signal transduction [TAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- leukocyte cell-cell adhesion [IDA]
- leukocyte migration [IDA]
- leukocyte tethering or rolling [IDA]
- membrane to membrane docking [IDA]
- myoblast migration [ISS]
- negative regulation of angiogenesis [IMP]
- positive regulation of focal adhesion assembly [ISS]
- regulation of actin cytoskeleton organization [TAS]
- regulation of cell adhesion [TAS]
- regulation of cell motility [TAS]
- regulation of establishment of cell polarity [TAS]
- regulation of focal adhesion assembly [TAS]
- regulation of keratinocyte differentiation [IMP]
- regulation of stress fiber assembly [TAS]
- signal transduction [TAS]
- smooth muscle contraction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway.
Aberrant splicing of the cyclin-dependent kinase-associated phosphatase, KAP, promotes glioblastoma invasion in a Cdc2-dependent manner. However, the mechanism by which this occurs is unknown. Here we show that miR-26a, which is often amplified in glioblastoma, promotes invasion in phosphatase and tensin homolog (PTEN)-competent and PTEN-deficient glioblastoma cells by directly downregulating KAP expression. Mechanistically, we find that KAP binds and activates ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID