TRDN
Gene Ontology Biological Process
- cellular calcium ion homeostasis [ISS]
- cytoplasmic microtubule organization [ISS]
- endoplasmic reticulum membrane organization [ISS]
- heart contraction [IMP]
- ion transmembrane transport [TAS]
- muscle contraction [TAS]
- negative regulation of ryanodine-sensitive calcium-release channel activity [TAS]
- positive regulation of cell communication by electrical coupling involved in cardiac conduction [ISS]
- positive regulation of ryanodine-sensitive calcium-release channel activity [ISS, TAS]
- regulation of cardiac muscle cell membrane potential [ISS]
- regulation of cell communication by electrical coupling [TAS]
- regulation of release of sequestered calcium ion into cytosol [TAS]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISS]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- calcium channel complex [ISS]
- cytoplasm [IDA]
- endoplasmic reticulum [ISS]
- integral component of membrane [TAS]
- junctional membrane complex [ISS]
- junctional sarcoplasmic reticulum membrane [ISS, TAS]
- plasma membrane [IDA]
- sarcoplasmic reticulum [ISS]
- sarcoplasmic reticulum lumen [TAS]
- sarcoplasmic reticulum membrane [TAS]
- voltage-gated calcium channel complex [ISS]
STX12
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.991988192 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.991988192, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
TRDN STX12 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9923 | BioGRID | 3092102 |
Curated By
- BioGRID