IL12A
Gene Ontology Biological Process
- cell cycle arrest [IDA]
- cell migration [IDA]
- defense response to Gram-positive bacterium [IEP]
- extrinsic apoptotic signaling pathway [IDA]
- immune response [TAS]
- negative regulation of interleukin-17 production [IDA]
- negative regulation of smooth muscle cell proliferation [IDA]
- positive regulation of NK T cell activation [IDA]
- positive regulation of T cell mediated cytotoxicity [IDA]
- positive regulation of T cell proliferation [IBA]
- positive regulation of cell adhesion [IDA]
- positive regulation of interferon-gamma production [IDA]
- positive regulation of lymphocyte proliferation [IDA]
- positive regulation of mononuclear cell proliferation [IMP]
- positive regulation of natural killer cell activation [IDA]
- positive regulation of natural killer cell mediated cytotoxicity [IDA]
- positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [IDA]
- positive regulation of smooth muscle cell apoptotic process [IDA]
- positive regulation of tyrosine phosphorylation of Stat4 protein [IDA]
- response to UV-B [IDA]
- response to lipopolysaccharide [IDA]
- response to virus [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
F11R
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.981391895 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.981391895, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
IL12A F11R | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9994 | BioGRID | 3053196 |
Curated By
- BioGRID