CCR1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [TAS]
- calcium ion transport [IDA]
- cell adhesion [TAS]
- cell surface receptor signaling pathway [TAS]
- cell-cell signaling [IDA]
- cellular calcium ion homeostasis [IDA]
- chemokine-mediated signaling pathway [IDA]
- chemotaxis [NAS]
- cytokine-mediated signaling pathway [NAS]
- dendritic cell chemotaxis [TAS]
- exocytosis [IDA]
- immune response [IDA]
- metabolic process [IDA]
- negative regulation of bone mineralization [IMP]
- negative regulation of gene expression [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of calcium ion transport [IDA]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of monocyte chemotaxis [IDA]
- positive regulation of osteoclast differentiation [IMP]
- response to wounding [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CDCA3
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.82307485 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.82307485, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
CCR1 CDCA3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.914 | BioGRID | 3067796 |
Curated By
- BioGRID