FGFR4
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- cell migration [IMP]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, IPI, TAS]
- glucose homeostasis [ISS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphate ion homeostasis [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of DNA biosynthetic process [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of cell proliferation [IDA, IGI]
- positive regulation of metalloenzyme activity [IMP]
- positive regulation of proteolysis [IMP]
- protein autophosphorylation [IDA]
- regulation of bile acid biosynthetic process [IMP]
- regulation of cholesterol homeostasis [ISS]
- regulation of extracellular matrix disassembly [IMP]
- regulation of lipid metabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
EPHA4
Gene Ontology Biological Process
- corticospinal tract morphogenesis [ISS]
- fasciculation of motor neuron axon [ISS]
- fasciculation of sensory neuron axon [ISS]
- motor neuron axon guidance [ISS]
- negative regulation of axon regeneration [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of Rho guanyl-nucleotide exchange factor activity [IDA]
- protein autophosphorylation [IDA]
- regulation of Rac GTPase activity [ISS]
- regulation of Rap GTPase activity [ISS]
- regulation of astrocyte differentiation [ISS]
- regulation of axonogenesis [ISS]
- regulation of dendritic spine morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Trans-activation of EphA4 and FGF receptors mediated by direct interactions between their cytoplasmic domains.
A yeast two-hybrid analysis has shown that the juxtamembrane region of FGF receptor 3 (FGFR3) interacts with the cytoplasmic domain of EphA4, which is a member of the largest family of receptor tyrosine kinases. Complex formation between the two receptors was shown to be mediated by direct interactions between the juxtamembrane domain of FGFR1, FGFR2, FGFR3, or FGFR4 and the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID