BAIT
CHD3
Mi-2a, Mi2-ALPHA, ZFH
chromodomain helicase DNA binding protein 3
GO Process (5)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
JUP
ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB
junction plakoglobin
GO Process (20)
GO Function (9)
GO Component (17)
Gene Ontology Biological Process
- adherens junction organization [TAS]
- bundle of His cell to Purkinje myocyte communication [IMP]
- cell junction assembly [TAS]
- cell migration [IMP]
- cell-cell junction organization [TAS]
- cellular response to indole-3-methanol [IDA]
- cytoskeletal anchoring at plasma membrane [NAS]
- desmosome assembly [IDA, IMP]
- detection of mechanical stimulus [IDA]
- endothelial cell-cell adhesion [ISS]
- establishment of protein localization to plasma membrane [IMP]
- positive regulation of canonical Wnt signaling pathway [IC]
- positive regulation of protein import into nucleus [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IBA]
- regulation of cell fate specification [IBA]
- regulation of cell proliferation [IDA]
- regulation of heart rate by cardiac conduction [IMP]
- single organismal cell-cell adhesion [IDA, IMP]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- catenin complex [IDA]
- cell-cell adherens junction [IDA]
- cell-cell junction [IDA]
- cytoplasm [IMP]
- cytoplasmic side of plasma membrane [ISS]
- cytoskeleton [ISS]
- cytosol [ISS]
- desmosome [IDA]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- gamma-catenin-TCF7L2 complex [IDA]
- hemidesmosome [ISS]
- intercalated disc [IDA]
- nucleus [IMP]
- plasma membrane [IDA, TAS]
- protein-DNA complex [IDA]
- zonula adherens [ISS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.
CHD3 and CHD4 (Chromodomain Helicase DNA binding protein), two highly similar representatives of the Mi-2 subfamily of SF2 helicases, are coexpressed in many cell lines and tissues and have been reported to act as the motor subunit of the NuRD complex (nucleosome remodeling and deacetylase activities). Besides CHD proteins, NuRD contains several repressors like HDAC1/2, MTA2/3 and MBD2/3, arguing for ... [more]
Nucleic Acids Res. Oct. 13, 2017; 45(18);10534-10554 [Pubmed: 28977666]
Throughput
- High Throughput
Additional Notes
- nuclear extract
Curated By
- BioGRID