BAIT
SNAI1
SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1
snail family zinc finger 1
GO Process (12)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- Notch signaling involved in heart development [ISS]
- epithelial to mesenchymal transition [IDA, ISS]
- mesoderm formation [ISS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IMP]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISS]
- negative regulation of vitamin D biosynthetic process [IDA]
- osteoblast differentiation [IEP]
- positive regulation of cell migration [IMP]
- positive regulation of epithelial to mesenchymal transition [IMP, TAS]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of tight junction assembly [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
DDX3X
CAP-Rf, DBX, DDX14, DDX3, HLP2
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
GO Process (29)
GO Function (14)
GO Component (6)
Gene Ontology Biological Process
- ATP catabolic process [IDA, TAS]
- DNA duplex unwinding [IDA]
- RNA secondary structure unwinding [IDA]
- cellular response to arsenic-containing substance [IDA]
- cellular response to osmotic stress [IDA]
- chromosome segregation [IMP]
- extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- innate immune response [IMP]
- intracellular signal transduction [IDA]
- intrinsic apoptotic signaling pathway [IMP]
- mature ribosome assembly [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of intrinsic apoptotic signaling pathway [IMP]
- negative regulation of protein complex assembly [IDA]
- negative regulation of translation [IMP]
- positive regulation of G1/S transition of mitotic cell cycle [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of chemokine (C-C motif) ligand 5 production [TAS]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of interferon-beta production [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of translation [IDA]
- positive regulation of translational initiation [IMP]
- positive regulation of viral genome replication [IMP]
- response to virus [IDA]
- stress granule assembly [IDA]
Gene Ontology Molecular Function- ATP-dependent DNA helicase activity [IDA]
- ATP-dependent RNA helicase activity [IDA]
- ATPase activity [IDA]
- DNA binding [IDA]
- RNA binding [IDA]
- RNA stem-loop binding [IDA]
- eukaryotic initiation factor 4E binding [IDA]
- mRNA 5'-UTR binding [IDA]
- poly(A) RNA binding [IDA]
- poly(A) binding [IDA]
- protein binding [IPI]
- ribosomal small subunit binding [IDA]
- transcription factor binding [IDA]
- translation initiation factor binding [IDA]
- ATP-dependent DNA helicase activity [IDA]
- ATP-dependent RNA helicase activity [IDA]
- ATPase activity [IDA]
- DNA binding [IDA]
- RNA binding [IDA]
- RNA stem-loop binding [IDA]
- eukaryotic initiation factor 4E binding [IDA]
- mRNA 5'-UTR binding [IDA]
- poly(A) RNA binding [IDA]
- poly(A) binding [IDA]
- protein binding [IPI]
- ribosomal small subunit binding [IDA]
- transcription factor binding [IDA]
- translation initiation factor binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.
The epithelial-mesenchymal transition (EMT) transcription factor SNAIL is associated with distant metastasis and poor prognosis of esophageal squamous cell carcinoma (ESCC) patients. The proteolysis of SNAIL is mediated by the ubiquitin-proteasome system. Several E3 ligases have been characterized to promote SNAIL ubiquitination and degradation. However, the reverse process - deubiquitination of SNAIL remains largely unknown. In this study, we performed ... [more]
Cancer Lett. Dec. 01, 2017; 418();125-134 [Pubmed: 29331416]
Throughput
- High Throughput
Additional Notes
- Source of SNAIL not clear
Curated By
- BioGRID