BAIT
NRAS
ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6, RP5-1000E10.2
neuroblastoma RAS viral (v-ras) oncogene homolog
GO Process (13)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BTK
AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA, RP1-164F3.2
Bruton agammaglobulinemia tyrosine kinase
GO Process (25)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- B cell activation [TAS]
- B cell receptor signaling pathway [IBA, TAS]
- Fc-epsilon receptor signaling pathway [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- T cell receptor signaling pathway [IBA]
- adaptive immune response [IBA, TAS]
- apoptotic signaling pathway [TAS]
- calcium-mediated signaling [TAS]
- cell differentiation [IBA]
- innate immune response [IBA, TAS]
- intracellular signal transduction [TAS]
- mesoderm development [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- positive regulation of B cell differentiation [TAS]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- protein phosphorylation [TAS]
- regulation of B cell apoptotic process [TAS]
- regulation of B cell cytokine production [TAS]
- regulation of cell proliferation [IBA]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
LZTR1 is a regulator of RAS ubiquitination and signaling.
In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding leucine zipper-like transcription regulator 1 (LZTR1) gene led to enhanced mitogen-activated protein kinase (MAPK) pathway activity and reduced sensitivity to tyrosine kinase inhibitors. Knockdown of the Drosophila LZTR1 ortholog CG3711 resulted in a Ras-dependent gain-of-function phenotype. Endogenous human LZTR1 ... [more]
Science Dec. 07, 2017; 362(6419);1171-1177 [Pubmed: 30442766]
Throughput
- High Throughput
Additional Notes
- prey proteins were identified with an avgP score of 1 in high throughput BioID proteomic screens using HRAS, KRAS4A, KRAS4B and NRAS as baits
Curated By
- BioGRID