KRAS
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of cell proliferation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of protein phosphorylation [IMP]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SLC26A6
Gene Ontology Biological Process
- angiotensin-activated signaling pathway [IDA]
- anion transport [IDA]
- bicarbonate transport [IDA, IMP]
- cellular response to cAMP [ISS]
- cellular response to fructose stimulus [ISS]
- cellular response to interferon-gamma [IDA]
- chloride transmembrane transport [IDA, IMP, ISS]
- chloride transport [IDA, IMP]
- epithelial fluid transport [ISS]
- formate transport [ISS]
- intestinal absorption [ISS]
- intracellular pH elevation [ISS]
- ion transport [TAS]
- mannitol transport [ISS]
- oxalate transport [IMP, ISS]
- oxalic acid secretion [ISS]
- positive regulation of dipeptide transmembrane transport [ISS]
- protein kinase C signaling [IDA]
- regulation of intracellular pH [IDA, IMP]
- sperm capacitation [ISS]
- sulfate transmembrane transport [IDA, IMP]
- sulfate transport [IMP, ISS]
- transepithelial chloride transport [IMP, ISS]
- transepithelial transport [ISS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function- PDZ domain binding [ISS]
- anion:anion antiporter activity [IDA, IMP, ISS]
- bicarbonate transmembrane transporter activity [IDA, IMP, ISS]
- chloride transmembrane transporter activity [IDA, IMP, ISS]
- efflux transmembrane transporter activity [ISS]
- formate efflux transmembrane transporter activity [ISS]
- formate transmembrane transporter activity [ISS]
- formate uptake transmembrane transporter activity [ISS]
- oxalate transmembrane transporter activity [IMP]
- protein binding [IPI]
- sulfate transmembrane transporter activity [IDA, IMP]
- PDZ domain binding [ISS]
- anion:anion antiporter activity [IDA, IMP, ISS]
- bicarbonate transmembrane transporter activity [IDA, IMP, ISS]
- chloride transmembrane transporter activity [IDA, IMP, ISS]
- efflux transmembrane transporter activity [ISS]
- formate efflux transmembrane transporter activity [ISS]
- formate transmembrane transporter activity [ISS]
- formate uptake transmembrane transporter activity [ISS]
- oxalate transmembrane transporter activity [IMP]
- protein binding [IPI]
- sulfate transmembrane transporter activity [IDA, IMP]
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.
Proximity-dependent biotin labeling (BioID) may identify new targets for cancers driven by difficult-to-drug oncogenes such as Ras. Therefore, BioID was used with wild-type (WT) and oncogenic mutant (MT) H-, K-, and N-Ras, identifying known interactors, including Raf and PI3K, as well as a common set of 130 novel proteins proximal to all Ras isoforms. A CRISPR screen of these proteins for ... [more]
Throughput
- High Throughput
Additional Notes
- BioID
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
KRAS SLC26A6 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 25 | BioGRID | 2991805 |
Curated By
- BioGRID