KRAS
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of cell proliferation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of protein phosphorylation [IMP]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ITGB1
Gene Ontology Biological Process
- B cell differentiation [IC]
- axon guidance [TAS]
- blood coagulation [TAS]
- calcium-independent cell-matrix adhesion [IGI]
- cell junction assembly [TAS]
- cell migration [TAS]
- cell-cell adhesion mediated by integrin [IEP]
- cell-matrix adhesion [IMP]
- cell-substrate adhesion [IMP]
- cellular defense response [TAS]
- extracellular matrix organization [TAS]
- heterotypic cell-cell adhesion [IMP]
- homophilic cell adhesion via plasma membrane adhesion molecules [TAS]
- integrin-mediated signaling pathway [IMP]
- leukocyte cell-cell adhesion [IDA]
- leukocyte migration [TAS]
- leukocyte tethering or rolling [IMP]
- mesodermal cell differentiation [IEP]
- negative regulation of anoikis [IMP]
- positive regulation of apoptotic process [IGI]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- regulation of collagen catabolic process [IDA]
- regulation of immune response [TAS]
- stress fiber assembly [IMP]
- transforming growth factor beta receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell surface [IDA]
- cytoplasm [IDA]
- extracellular vesicular exosome [IDA]
- filopodium [IDA]
- focal adhesion [IDA]
- integrin alpha1-beta1 complex [IDA]
- integrin alpha10-beta1 complex [IDA]
- integrin alpha11-beta1 complex [IDA]
- integrin alpha2-beta1 complex [IDA]
- integrin alpha3-beta1 complex [IDA]
- integrin alpha8-beta1 complex [TAS]
- integrin complex [NAS]
- invadopodium membrane [IDA]
- membrane [IDA]
- membrane raft [IDA]
- neuromuscular junction [IDA]
- plasma membrane [IDA, NAS, TAS]
- receptor complex [IDA]
- ruffle [TAS]
- ruffle membrane [IDA, NAS]
- sarcolemma [IDA]
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.
In human cancers, oncogenic mutations commonly occur in the RAS genes KRAS, NRAS, or HRAS, but there are no clinical RAS inhibitors. Mutations are more prevalent in KRAS, possibly suggesting a unique oncogenic activity mediated by KRAS-specific interaction partners, which might be targeted. Here, we determine the specific protein interactomes of each RAS isoform by BirA proximity-dependent biotin identification. The ... [more]
Quantitative Score
- 16.43807482 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- BioID system:Biotin-labled proteins with at least a 2-fold enrichment and p-value < 0.05 were considered significant.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KRAS ITGB1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | - | BioGRID | 3343226 | |
| KRAS ITGB1 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | 2529402 | |
| KRAS ITGB1 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 445 | BioGRID | 2991427 | |
| KRAS ITGB1 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | 2548184 |
Curated By
- BioGRID