BAIT
PKD1
PBP, Pc-1, TRPP1
polycystic kidney disease 1 (autosomal dominant)
GO Process (34)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- JAK-STAT cascade [ISS]
- anatomical structure morphogenesis [TAS]
- branching morphogenesis of an epithelial tube [IDA]
- calcium ion transmembrane transport [ISS]
- calcium-independent cell-matrix adhesion [TAS]
- cartilage development [IEP]
- cell cycle arrest [ISS]
- cell-matrix adhesion [TAS]
- cytoplasmic sequestering of transcription factor [ISS]
- detection of mechanical stimulus [IBA, ISS]
- digestive tract development [IEP]
- embryonic placenta development [ISS]
- genitalia development [IEP]
- heart development [IEP]
- homophilic cell adhesion via plasma membrane adhesion molecules [TAS]
- in utero embryonic development [ISS]
- kidney development [ISS]
- lung epithelium development [IEP]
- mesonephric duct development [IEP]
- mesonephric tubule development [IEP]
- metanephric ascending thin limb development [IEP]
- metanephric collecting duct development [IEP]
- metanephric distal tubule morphogenesis [IEP]
- metanephric proximal tubule development [IEP]
- neural tube development [IEP]
- peptidyl-serine phosphorylation [ISS]
- placenta blood vessel development [ISS]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- positive regulation of protein binding [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein export from nucleus [ISS]
- regulation of proteasomal protein catabolic process [IDA]
- skin development [IEP]
- spinal cord development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SRC
ASV, SRC1, c-SRC, p60-Src, RP5-823N20.1
SRC proto-oncogene, non-receptor tyrosine kinase
GO Process (50)
GO Function (17)
GO Component (10)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- Ras protein signal transduction [TAS]
- T cell costimulation [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- bone resorption [IBA, ISS]
- cell adhesion [IBA]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to progesterone stimulus [ISS]
- central nervous system development [IBA]
- epidermal growth factor receptor signaling pathway [IBA, TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [IBA, TAS]
- integrin-mediated signaling pathway [IMP]
- intracellular estrogen receptor signaling pathway [IBA]
- intracellular signal transduction [IDA]
- leukocyte migration [TAS]
- membrane organization [TAS]
- negative regulation of anoikis [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of focal adhesion assembly [ISS]
- negative regulation of intrinsic apoptotic signaling pathway [IMP]
- negative regulation of mitochondrial depolarization [IMP]
- negative regulation of protein homooligomerization [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- osteoclast development [IBA]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA]
- platelet activation [TAS]
- platelet-derived growth factor receptor signaling pathway [IBA]
- positive regulation of integrin activation [TAS]
- positive regulation of protein kinase B signaling [IMP]
- progesterone receptor signaling pathway [IBA, ISS]
- protein autophosphorylation [IDA]
- regulation of bone resorption [TAS]
- regulation of caveolin-mediated endocytosis [IMP]
- regulation of cell cycle [IBA]
- regulation of cell proliferation [IBA]
- regulation of cell-cell adhesion [IMP]
- regulation of early endosome to late endosome transport [IMP]
- regulation of epithelial cell migration [IMP]
- regulation of podosome assembly [IBA]
- regulation of vascular permeability [TAS]
- response to interleukin-1 [IMP]
- signal complex assembly [TAS]
- signal transduction [TAS]
- stress fiber assembly [IMP]
- transforming growth factor beta receptor signaling pathway [IMP]
Gene Ontology Molecular Function- SH2 domain binding [IPI]
- SH3/SH2 adaptor activity [TAS]
- enzyme binding [IPI]
- ephrin receptor binding [IPI]
- growth factor receptor binding [IPI]
- heme binding [IDA]
- hormone receptor binding [IBA]
- integrin binding [TAS]
- ion channel binding [IPI]
- kinase activity [TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA, TAS]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA, TAS]
- protein tyrosine kinase activity [EXP, IDA, TAS]
- receptor binding [IPI]
- scaffold protein binding [IPI]
- SH2 domain binding [IPI]
- SH3/SH2 adaptor activity [TAS]
- enzyme binding [IPI]
- ephrin receptor binding [IPI]
- growth factor receptor binding [IPI]
- heme binding [IDA]
- hormone receptor binding [IBA]
- integrin binding [TAS]
- ion channel binding [IPI]
- kinase activity [TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA, TAS]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA, TAS]
- protein tyrosine kinase activity [EXP, IDA, TAS]
- receptor binding [IPI]
- scaffold protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals.
Mutations in PKD1, the gene encoding for the receptor Polycystin-1 (PC-1), cause autosomal dominant polycystic kidney disease (ADPKD). The cytoplasmic C-terminus of PC-1 contains a coiled-coil domain that mediates an interaction with the PKD2 gene product, Polycystin-2 (PC-2). Here we identify a novel domain in the PC-1 C-terminal tail, a polyproline motif mediating an interaction with Src homology domain 3 ... [more]
PLoS ONE Sep. 14, 2010; 5(9);e12719 [Pubmed: 20856870]
Throughput
- Low Throughput
Curated By
- BioGRID