BAIT

AGK

CATC5, CTRCT38, MTDPS10, MULK
acylglycerol kinase
GO Process (0)
GO Function (0)
GO Component (2)

Gene Ontology Cellular Component

Homo sapiens
PREY

SLC39A14

LZT-Hs4, NET34, ZIP14, cig19
solute carrier family 39 (zinc transporter), member 14
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria.

Vukotic M, Nolte H, Koenig T, Saita S, Ananjew M, Krueger M, Tatsuta T, Langer T

Mutations in mitochondrial acylglycerol kinase (AGK) cause Sengers syndrome, which is characterized by cataracts, hypertrophic cardiomyopathy, and skeletal myopathy. AGK generates phosphatidic acid and lysophosphatidic acid, bioactive phospholipids involved in lipid signaling and the regulation of tumor progression. However, the molecular mechanisms of the mitochondrial pathology remain enigmatic. Determining its mitochondrial interactome, we have identified AGK as a constituent of the ... [more]

Mol. Cell Aug. 03, 2017; 67(3);471-483.e7 [Pubmed: 28712724]

Throughput

  • High Throughput

Curated By

  • BioGRID