BAIT
BIRC3
AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2
baculoviral IAP repeat containing 3
GO Process (23)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- MyD88-independent toll-like receptor signaling pathway [TAS]
- NIK/NF-kappaB signaling [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- cell surface receptor signaling pathway [TAS]
- inhibition of cysteine-type endopeptidase activity involved in apoptotic process [IBA]
- innate immune response [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of necroptotic process [IBA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [TAS]
- positive regulation of protein ubiquitination [IDA]
- protein ubiquitination [IDA]
- regulation of RIG-I signaling pathway [TAS]
- regulation of apoptotic process [IMP]
- regulation of cysteine-type endopeptidase activity [TAS]
- regulation of inflammatory response [TAS]
- regulation of innate immune response [TAS]
- regulation of necroptotic process [IMP]
- regulation of nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- regulation of toll-like receptor signaling pathway [TAS]
- spindle assembly involved in mitosis [IBA]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DNAJA3
HCA57, TID1, hTID-1
DnaJ (Hsp40) homolog, subfamily A, member 3
GO Process (18)
GO Function (7)
GO Component (13)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- mitochondrion organization [IBA]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of interferon-gamma-mediated signaling pathway [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- neuromuscular junction development [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of protein ubiquitination [IDA]
- protein folding [IDA]
- protein refolding [IBA]
- protein stabilization [IDA]
- response to interferon-gamma [IDA]
- skeletal muscle acetylcholine-gated channel clustering [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- I-kappaB/NF-kappaB complex [IDA]
- IkappaB kinase complex [IDA]
- actin filament [IDA]
- cytoplasm [IDA]
- cytosol [IMP]
- extrinsic component of plasma membrane [ISS]
- intracellular membrane-bounded organelle [IDA]
- mitochondrial matrix [IDA]
- mitochondrial nucleoid [IDA]
- mitochondrion [IDA]
- neuromuscular junction [ISS]
- nucleus [IDA]
- postsynaptic membrane [ISS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.
Alternative 3' untranslated regions (3' UTRs) are widespread, but their functional roles are largely unknown. We investigated the function of the long BIRC3 3' UTR, which is upregulated in leukemia. The 3' UTR does not regulate BIRC3 protein localization or abundance but is required for CXCR4-mediated B cell migration. We established an experimental pipeline to study the mechanism of regulation and ... [more]
Mol. Cell Dec. 16, 2018; 74(4);701-712.e9 [Pubmed: 30948266]
Throughput
- High Throughput
Additional Notes
- assayed using SILAC IP (stable isotope labeling by amino acids in cell culture-based quantitative immunoprecipitation)
Curated By
- BioGRID