BAIT
NACA
NACA1, skNAC, HSD48
nascent polypeptide-associated complex alpha subunit
GO Process (10)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- cardiac ventricle development [ISS]
- heart trabecula morphogenesis [ISS]
- negative regulation of striated muscle cell apoptotic process [ISS]
- negative regulation of transcription from RNA polymerase II promoter involved in heart development [ISS]
- positive regulation of cell proliferation involved in heart morphogenesis [ISS]
- positive regulation of skeletal muscle tissue growth [ISS]
- positive regulation of transcription from RNA polymerase II promoter involved in heart development [ISS]
- regulation of skeletal muscle fiber development [ISS]
- skeletal muscle tissue regeneration [ISS]
- translation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LMO7
FBX20, FBXO20, LOMP, RP11-332E3.2
LIM domain 7
GO Process (1)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dephosphorylation of the transcriptional cofactor NACA by the PP1A phosphatase enhances cJUN transcriptional activity and osteoblast differentiation.
The transcriptional cofactor nascent polypeptide-associated complex and co-regulator ? (NACA) regulates osteoblast maturation and activity. NACA functions, at least in part, by binding to Jun proto-oncogene, AP-1 transcription factor subunit (cJUN) and potentiating the transactivation of AP-1 targets such as osteocalcin (Bglap) and matrix metallopeptidase 9 (Mmp9). NACA activity is modulated by phosphorylation carried out by several kinases, but a ... [more]
J. Biol. Chem. Dec. 17, 2018; 294(20);8184-8196 [Pubmed: 30948508]
Throughput
- High Throughput
Curated By
- BioGRID