BAIT
STX2
EPIM, EPM, STX2A, STX2B, STX2C
syntaxin 2
GO Process (11)
GO Function (5)
GO Component (10)
Gene Ontology Biological Process
- acrosome reaction [ISS]
- ectoderm development [TAS]
- intracellular protein transport [IBA]
- organ morphogenesis [TAS]
- protein oligomerization [IDA]
- regulation of blood coagulation [IMP]
- regulation of cytoskeleton organization [IDA]
- response to hydroperoxide [IDA]
- signal transduction [TAS]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- vesicle docking [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
STX12
STX13, STX14, RP3-426I6.4
syntaxin 12
GO Process (5)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID