BAIT
F11R
CD321, JAM, JAM1, JAMA, JCAM, KAT, PAM-1, RP11-544M22.2
F11 receptor
GO Process (8)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MYADM
SB135, UNQ553/PRO1110
myeloid-associated differentiation marker
GO Process (12)
GO Function (0)
GO Component (6)
Gene Ontology Biological Process
- cell-cell junction maintenance [IMP]
- establishment of endothelial barrier [IMP]
- membrane raft organization [IMP]
- negative regulation of actin filament polymerization [IMP]
- negative regulation of gene expression [IMP]
- negative regulation of heterotypic cell-cell adhesion [IDA]
- negative regulation of protein kinase C signaling [IMP]
- negative regulation of protein phosphorylation [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [IMP]
- protein targeting to plasma membrane [IMP]
- regulation of cell-substrate adhesion [IMP]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID