F11R
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PARD3
Gene Ontology Biological Process
- apical constriction [IGI]
- centrosome localization [IMP]
- establishment of epithelial cell polarity [ISO]
- establishment or maintenance of cell polarity [TAS]
- microtubule cytoskeleton organization [IMP]
- myelination in peripheral nervous system [IMP]
- negative regulation of peptidyl-threonine phosphorylation [IMP]
- positive regulation of myelination [IMP]
- protein targeting to membrane [ISO]
- regulation of actin filament-based process [IGI]
- regulation of cellular localization [ISO]
- single organismal cell-cell adhesion [IC]
- tight junction assembly [ISO]
- wound healing, spreading of cells [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Schmidt-Lanterman incisure [IDA]
- adherens junction [IDA]
- apical part of cell [IDA]
- axonal growth cone [ISO]
- cell cortex [IDA]
- cell junction [IDA, ISO]
- cell-cell adherens junction [IDA]
- cell-cell junction [IDA, ISO]
- cytoplasm [IDA]
- internode region of axon [IDA]
- intracellular [ISO]
- lateral loop [IDA]
- neuronal cell body [ISO]
- protein complex [IDA, ISO]
- spindle [IDA]
- tight junction [IDA, ISO]
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM).
The establishment and maintenance of cellular polarity are critical for the development of multicellular organisms. PAR (partitioning-defective) proteins were identified in Caenorhabditis elegans as determinants of asymmetric cell division and polarized cell growth. Recently, vertebrate orthologues of two of these proteins, ASIP/PAR-3 and PAR-6, were found to form a signalling complex with the small GTPases Cdc42/Rac1 and with atypical protein ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PARD3 F11R | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| F11R PARD3 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID