BAIT
MAGEA3
CT1.3, HIP8, HYPD, MAGE3, MAGEA6
melanoma antigen family A, 3
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
PPP3CB
CALNA2, CALNB, CNA2, PP2Bbeta, RP11-345K20.1
protein phosphatase 3, catalytic subunit, beta isozyme
GO Process (21)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell activation [TAS]
- T cell proliferation [NAS]
- axon extension [TAS]
- calcineurin-NFAT signaling cascade [IDA]
- calcium ion-dependent exocytosis [ISS]
- cellular response to drug [IDA]
- dephosphorylation [TAS]
- innate immune response [TAS]
- learning [TAS]
- memory [TAS]
- positive regulation of NFAT protein import into nucleus [IDA]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [NAS]
- protein dephosphorylation [ISS]
- protein phosphorylation [ISS]
- regulation of insulin secretion [ISS]
- regulation of synaptic plasticity [TAS]
- signal transduction [NAS]
- social behavior [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Regulation of MAGE-A3/6 by the CRL4-DCAF12 ubiquitin ligase and nutrient availability.
Melanoma antigen genes (MAGEs) are emerging as important oncogenic drivers that are normally restricted to expression in male germ cells but are aberrantly expressed in cancers and promote tumorigenesis. Mechanistically, MAGEs function as substrate specifying subunits of E3 ubiquitin ligases. Thus, the activation of germline-specific genes in cancer can drive metabolic and signaling pathways through altered ubiquitination to promote tumorigenesis. ... [more]
EMBO Rep. Dec. 01, 2018; 20(7);e47352 [Pubmed: 31267705]
Throughput
- High Throughput
Curated By
- BioGRID