BAIT
PDE6D
JBTS22, PDED
phosphodiesterase 6D, cGMP-specific, rod, delta
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ARL2
2610009M23Rik, AI115441, AW553335
ADP-ribosylation factor-like 2
GO Process (7)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The complex of Arl2-GTP and PDE delta: from structure to function.
Arf-like (Arl) proteins are close relatives of the Arf regulators of vesicular transport, but their function is unknown. Here, we present the crystal structure of full-length Arl2-GTP in complex with its effector PDE delta solved in two crystal forms (Protein Data Bank codes 1KSG, 1KSH and 1KSJ). Arl2 shows a dramatic conformational change from the GDP-bound form, which suggests that ... [more]
EMBO J. May. 01, 2002; 21(9);2095-106 [Pubmed: 11980706]
Throughput
- Low Throughput
Curated By
- BioGRID