BTK
Gene Ontology Biological Process
- B cell activation [TAS]
- B cell receptor signaling pathway [IBA, TAS]
- Fc-epsilon receptor signaling pathway [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- T cell receptor signaling pathway [IBA]
- adaptive immune response [IBA, TAS]
- apoptotic signaling pathway [TAS]
- calcium-mediated signaling [TAS]
- cell differentiation [IBA]
- innate immune response [IBA, TAS]
- intracellular signal transduction [TAS]
- mesoderm development [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- positive regulation of B cell differentiation [TAS]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- protein phosphorylation [TAS]
- regulation of B cell apoptotic process [TAS]
- regulation of B cell cytokine production [TAS]
- regulation of cell proliferation [IBA]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PRKD1
Gene Ontology Biological Process
- Golgi organization [IMP]
- Golgi vesicle transport [ISS]
- cell proliferation [TAS]
- cellular response to oxidative stress [IDA]
- cellular response to vascular endothelial growth factor stimulus [IGI, IMP]
- integrin-mediated signaling pathway [TAS]
- intracellular signal transduction [IMP]
- negative regulation of cell death [IMP]
- negative regulation of endocytosis [TAS]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of CREB transcription factor activity [IGI]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of angiogenesis [IGI, IMP]
- positive regulation of blood vessel endothelial cell migration [IGI, IMP]
- positive regulation of endothelial cell chemotaxis [IMP]
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [IGI, IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IGI]
- positive regulation of histone deacetylase activity [IGI]
- positive regulation of neuron projection development [IMP]
- positive regulation of osteoblast differentiation [ISS]
- positive regulation of peptidyl-serine phosphorylation [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein autophosphorylation [TAS]
- protein kinase D signaling [IGI]
- regulation of integrin-mediated signaling pathway [TAS]
- regulation of keratinocyte proliferation [ISS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- sphingolipid biosynthetic process [TAS]
- sphingolipid metabolic process [TAS]
- vascular endothelial growth factor receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Bruton's tyrosine kinase (Btk) associates with protein kinase C mu.
Bruton's tyrosine kinase (Btk) is considered an essential signal transducer in B-cells. Mutational defects are associated with a severe immunodeficiency syndrome, X-chromosome linked agammaglobulinemia (XLA). Here we show by coimmunoprecipitation that a member of the protein kinase C (PKC) family, PKCmu, is constitutively associated with Btk. Neither antigen receptor (Ig) crosslinking nor stimulation of B-cells with phorbol ester or H(2)O(2) ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BTK PRKD1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PRKD1 BTK | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID