BAIT
GRB10
GRB-IR, Grb-10, IRBP, MEG1, RSS
growth factor receptor-bound protein 10
GO Process (8)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- insulin receptor signaling pathway [ISS, TAS]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of glucose import [ISS]
- negative regulation of glycogen biosynthetic process [ISS]
- negative regulation of insulin receptor signaling pathway [ISS]
- positive regulation of phosphorylation [ISS]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- response to insulin [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
PPP3CB
CALNA2, CALNB, CNA2, PP2Bbeta, RP11-345K20.1
protein phosphatase 3, catalytic subunit, beta isozyme
GO Process (21)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell activation [TAS]
- T cell proliferation [NAS]
- axon extension [TAS]
- calcineurin-NFAT signaling cascade [IDA]
- calcium ion-dependent exocytosis [ISS]
- cellular response to drug [IDA]
- dephosphorylation [TAS]
- innate immune response [TAS]
- learning [TAS]
- memory [TAS]
- positive regulation of NFAT protein import into nucleus [IDA]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [NAS]
- protein dephosphorylation [ISS]
- protein phosphorylation [ISS]
- regulation of insulin secretion [ISS]
- regulation of synaptic plasticity [TAS]
- signal transduction [NAS]
- social behavior [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.
Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRASG13D) affects PPIN structure and function of the Epidermal Growth Factor Receptor (EGFR) network in colorectal cancer (CRC) cells. Mapping >6000 PPIs shows that this network is ... [more]
Nat Commun Dec. 24, 2019; 11(1);499 [Pubmed: 31980649]
Throughput
- High Throughput
Curated By
- BioGRID