BTK
Gene Ontology Biological Process
- B cell activation [TAS]
- B cell receptor signaling pathway [IBA, TAS]
- Fc-epsilon receptor signaling pathway [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- T cell receptor signaling pathway [IBA]
- adaptive immune response [IBA, TAS]
- apoptotic signaling pathway [TAS]
- calcium-mediated signaling [TAS]
- cell differentiation [IBA]
- innate immune response [IBA, TAS]
- intracellular signal transduction [TAS]
- mesoderm development [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- positive regulation of B cell differentiation [TAS]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- protein phosphorylation [TAS]
- regulation of B cell apoptotic process [TAS]
- regulation of B cell cytokine production [TAS]
- regulation of cell proliferation [IBA]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KHDRBS1
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [ISS]
- cell cycle arrest [TAS]
- cell proliferation [TAS]
- cell surface receptor signaling pathway [IDA]
- mRNA processing [TAS]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of RNA export from nucleus [IDA]
- positive regulation of translational initiation [IDA]
- regulation of RNA export from nucleus [ISS]
- regulation of protein stability [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The SH3 domain of Bruton's tyrosine kinase interacts with Vav, Sam68 and EWS.
Bruton tyrosine kinase (BTK) is a cytoplasmic protein tyrosine kinase which controls crucial steps of differentiation of B lymphocytes. Mutations affecting either the PH, SH3, SH2 or kinase domain of BTK all give rise to X linked agammaglobulinaemia (XLA) in humans. In this study, the authors report that the BTK-SH3 domain binds to a set of proteins expressed in pro-B, ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
KHDRBS1 BTK | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | Low | - | BioGRID | - |
Curated By
- BioGRID