BAIT
PRKCI
DXS1179E, PKCI, nPKC-iota
protein kinase C, iota
GO Process (21)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- cell junction assembly [TAS]
- cell-cell junction organization [IMP, TAS]
- cellular response to insulin stimulus [ISS]
- cytoskeleton organization [NAS]
- establishment or maintenance of epithelial cell apical/basal polarity [TAS]
- membrane organization [NAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of glial cell apoptotic process [IMP]
- negative regulation of neuron apoptotic process [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of endothelial cell apoptotic process [IMP]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- positive regulation of glial cell proliferation [IMP]
- positive regulation of glucose import [ISS]
- positive regulation of neuron projection development [IMP]
- protein phosphorylation [IDA]
- protein targeting to membrane [NAS]
- secretion [NAS]
- tight junction assembly [TAS]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ASPH
AAH, BAH, CASQ2BP1, FDLAB, HAAH, JCTN, junctin
aspartate beta-hydroxylase
GO Process (17)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity [IDA]
- activation of store-operated calcium channel activity [IDA]
- calcium ion transmembrane transport [IDA]
- cellular response to calcium ion [IDA]
- detection of calcium ion [TAS]
- muscle contraction [TAS]
- positive regulation of calcium ion transport into cytosol [IDA]
- positive regulation of intracellular protein transport [IDA]
- positive regulation of proteolysis [IDA]
- positive regulation of ryanodine-sensitive calcium-release channel activity [TAS]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [ISS, TAS]
- regulation of cell communication by electrical coupling [TAS]
- regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [TAS]
- regulation of ryanodine-sensitive calcium-release channel activity [TAS]
- response to ATP [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- calcium channel complex [TAS]
- cortical endoplasmic reticulum [IDA]
- endoplasmic reticulum [IDA]
- endoplasmic reticulum membrane [NAS]
- integral component of endoplasmic reticulum membrane [IDA]
- junctional sarcoplasmic reticulum membrane [TAS]
- plasma membrane [IDA]
- sarcoplasmic reticulum lumen [TAS]
- sarcoplasmic reticulum membrane [TAS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.
Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRASG13D) affects PPIN structure and function of the Epidermal Growth Factor Receptor (EGFR) network in colorectal cancer (CRC) cells. Mapping >6000 PPIs shows that this network is ... [more]
Nat Commun Dec. 24, 2019; 11(1);499 [Pubmed: 31980649]
Throughput
- High Throughput
Curated By
- BioGRID