BAIT

ING1

p24ING1c, p33, p33ING1, p33ING1b, p47, p47ING1a, RP11-8D7.1
inhibitor of growth family, member 1
GO Process (1)
GO Function (2)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

SMARCC2

BAF170, CRACC2, Rsc8
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Autism spectrum disorder (ASD) Project
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1).

Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D

Sin3 is an evolutionarily conserved corepressor that exists in different complexes with the histone deacetylases HDAC1 and HDAC2. Sin3-HDAC complexes are believed to deacetylate nucleosomes in the vicinity of Sin3-regulated promoters, resulting in a repressed chromatin structure. We have previously found that a human Sin3-HDAC complex includes HDAC1 and HDAC2, the histone-binding proteins RbAp46 and RbAp48, and two novel polypeptides ... [more]

Mol. Cell. Biol. Feb. 01, 2002; 22(3);835-48 [Pubmed: 11784859]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
SMARCC2 ING1
Co-fractionation
Co-fractionation

Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.

High-BioGRID
3452894

Curated By

  • BioGRID